期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 63, 期 -, 页码 135-143出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.12.009
关键词
PARP; ARTD; Metabolism; Mitochondria; Diabetes; Obesity
资金
- NKFIH [K108308]
- Momentum fellowship of the Hungarian Academy of Sciences
- University of Debrecen
- European Union
- European Regonal Development Fund
- [GINOP-2.3.2-15-2016-00006]
Poly(ADP-ribosyl) ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic transcription factors (e.g. SIRT1, nuclear receptors, SREBPs) and certain cellular energy sensors. PARP over-activation can cause damage to mitochondrial terminal oxidation, while the inhibition of PARP-1 or PARP-2 can induce mitochondrial oxidation by enhancing the mitotropic tone of gene transcription and signal transduction. These PARP-mediated processes impact on higher order metabolic regulation that modulates lipid metabolism, circadian oscillations and insulin secretion and signaling. PARP-1, PARP-2 and PARP-7 are related to metabolic diseases such as diabetes, alcoholic and non-alcoholic fatty liver disease (AFLD, NAFLD), or on a broader perspective to Warburg metabolism in cancer or the metabolic diseases accompanying aging. (C) 2016 Elsevier Ltd. All rights reserved.
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