期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 67, 期 -, 页码 23-28出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.12.004
关键词
Tumor-derived exosomes; microRNAs; Cancer; Immune system; Microenvironment
资金
- Hyundai Hope on Wheels grant
- William Lawrence & Blanche Hughes Foundation grant
- Jean Perkins Foundation grant
- Nautica Malibu Triathlon Funds
- STOP Cancer grant
- Hugh and Audy Lou Colvin Foundation grant
- National Cancer Institute [P30CA014089]
- Alex's Lemonade Stand Foundation grant
In recent years there has been an increasing interest of the scientific community on exosome research, with particular emphasis on the mechanisms by which tumor-derived exosomes can promote tumor growth. Particularly, exosome-mediated immune-escape is under deep investigation and still represents a quite controversial issue. Tumor-derived exosomes are carriers of information able to reprogram functions of immune target cells, influencing their development, maturation, and antitumor activities. They deliver proteins similar to those of the parent cancer cells, but also genetic messages like genomic DNA, mRNA, and microRNAs (miRNAs) that ultimately share the so called tumor microenvironment in a pro-tumoral fashion. The content of tumor-derived exosomes could be implicated in several signaling pathways operating in the tumor microenvironment, providing a further modality of dys-regulation of antitumor immunity. The aim of this review is to provide a state-of-the-art highlight of to the most recent discoveries in the field of interaction between tumor-derived exosomic miRNAs and the cells of immune system. (C) 2016 Elsevier Ltd. All rights reserved.
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