期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 67, 期 -, 页码 161-169出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2016.07.029
关键词
Tissue mechanics; Epithelium; Jamming; Deformation; Collective motion; Morphogenesis
资金
- Alfred P. Sloan Foundation
- Gordon and Betty Moore Foundation
- Research Corporation for Scientific Advancement
- Syracuse University HTC Campus Grid
- NSF award [ACI-1541396]
- Soft Matter Program at Syracuse University
- [NSF-BMMB-1334611]
- [NSF-DMR-1352184]
- [NIH-1R01GM117598-01]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1352184] Funding Source: National Science Foundation
In multi-cellular organisms, morphogenesis translates processes at the cellular scale into tissue deformation at the scale of organs and organisms. To understand how biochemical signaling regulates tissue form and function, we must understand the mechanical forces that shape cells and tissues. Recent progress in developing mechanical models for tissues has led to quantitative predictions for how cell shape changes and polarized cell motility generate forces and collective behavior on the tissue scale. In particular, much insight has been gained by thinking about biological tissues as physical materials composed of cells. Here we review these advances and discuss how they might help shape future experiments in developmental biology. (C) 2016 Elsevier Ltd. All rights reserved.
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