期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 72, 期 -, 页码 45-55出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.10.033
关键词
Drosophila; Muscle development; Membrane fusion; Actin cytoskeleton
资金
- NIH [GM078318, AR108981]
- National Cancer Institute [P30 CA 008748]
- [SFRH/BD/52041/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/52041/2012] Funding Source: FCT
The study of Drosophila muscle development dates back to the middle of the last century. Since that time, Drosophila has proved to be an ideal system for studying muscle development, differentiation, function, and disease. As in humans, Drosophila muscle forms via a series of conserved steps, starting with muscle specification, myoblast fusion, attachment to tendon cells, interactions with motorneurons, and sarcomere and myofibril formation. The genes and mechanisms required for these processes share striking similarities to those found in humans. The highly tractable genetic system and imaging approaches available in Drosophila allow for an efficient interrogation of muscle biology and for application of what we learn to other systems. In this article, we review our current understanding of muscle development in Drosophila, with a focus on myoblast fusion, the process responsible for the generation of syncytial muscle cells. We also compare and contrast those genes required for fusion in Drosophila and vertebrates. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据