期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 81, 期 -, 页码 71-77出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.09.008
关键词
Testis; Planar cell polarity; Spermatogenesis; Sertoli cell; Blood; testis barrier
资金
- National Institutes of Health [NICHDR01 HD056034, U54 HD029990, LSK/14-15/P06]
- Hong Kong Research Grants Council (RGC) [GRF 17100816, GRF 771513]
- National Natural Science Foundation of China (NSFC)/RGC Joint Research Scheme grant [N_HKU 717/12]
- Hong Kong University Seed Funding for Basic Research
- The Fai Lau Memorial Fellowship
- The S.Y. Law Memorial Fellowship
In adult mammalian testes, spermatids, most notably step 17-19 spermatids in stage IV-VIII tubules, are aligned with their heads pointing toward the basement membrane and their tails toward the tubule lumen. On the other hand, these polarized spermatids also align across the plane of seminiferous epithelium, mimicking planar cell polarity (PCP) found in other hair cells in cochlea (inner ear). This orderly alignment of developing spermatids during spermiogenesis is important to support spermatogenesis, such that the maximal number of developing spermatids can be packed and supported by a fixed population of differentiated Sertoli cells in the limited space of the seminiferous epithelium in adult testes. In this review, we provide emerging evidence to demonstrate spermatid PCP in the seminiferous epithelium to support spermatogenesis. We also review findings in the field regarding the biology of spermatid cellular polarity (e.g., head-tail polarity and apico-basal polarity) and its inter-relationship to spermatid PCP. Furthermore, we also provide a hypothetical concept on the importance of PCP proteins in endocytic vesicle-mediated protein trafficking events to support spermatogenesis through protein endocytosis and recycling. (C) 2017 Elsevier Ltd. All rights reserved.
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