期刊
SEMINARS IN CANCER BIOLOGY
卷 51, 期 -, 页码 160-169出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.08.003
关键词
Ovarian cancer; DNA methylation; Chromatin
类别
资金
- NCI NIH HHS [R25 CA092049, P50 CA136393, P30 CA015083, R01 CA122443] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R25CA092049, P30CA015083, P50CA136393, R01CA122443] Funding Source: NIH RePORTER
Ovarian cancer is a disease with a poor prognosis and little progress has been made to improve treatment. It is now recognized that there are several histotypes of ovarian cancer, each with distinct epidemiologic and genomic characteristics. Cancer therapy is moving beyond classical chemotherapy to include epigenetic approaches. Epigenetics is the dynamic regulation of gene expression by DNA methylation and histone post translational modification in response to environmental cues. Improvement in technology to study DNA methylation has enabled a more agnostic approach and, with larger samples sets, has begun to unravel how epi-genetics contributes to the etiology, response to chemotherapy and prognosis in of ovarian cancer. Investigations into histone modifications in ovarian cancer are more nascent. Much more is needed to be done to fully realize the potential that epigenetics holds for ovarian cancer clinical care.
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