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Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

期刊

SEMINARS IN CANCER BIOLOGY
卷 43, 期 -, 页码 157-179

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2017.02.003

关键词

Cellular acidification in cancer treatment; Cellular acidifiers; pH, NHE, cancer and neurodegenerative diseases; Ion channels in cancer and neurodegeneration; Growth factors in cancer and neurodegenerative diseases

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资金

  1. Mercedes Castresana Foundation, Vitoria, Spain
  2. Association for Proton Cancer Research and Treatment (APCRT), Madrid, Spain
  3. BBSRC UK
  4. University of Nottingham UK
  5. Ministere de la Recherche et des Technologies
  6. Inserm
  7. Ligue Nationale Contre le Cancer
  8. Region Centre (grant NaVMetarget)
  9. project ARD2020 Biodrugs
  10. Association CANCEN

向作者/读者索取更多资源

Wisdom is to walk in two opposite directions at the same time Lao Tse During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopathogenesis to treatment. The abnormalities of intracellular alkalinization along with extracellular acidification of all types of solid tumors and leukemic cells have never been described in any other disease and now appear to be a specific hallmark of malignancy. As a consequence of this intracellular acid-base homeostatic failure, the attempt to induce cellular acidification using proton transport inhibitors and other intracellular acidifiers of different origins is becoming a new therapeutic concept and selective target of cancer treatment, both as a metabolic mediator of apoptosis and in the overcoming of multiple drug resistance (MDR). Importantly, there is increasing data showing that different ion channels contribute to mediate significant aspects of cancer pH regulation and etiopathogenesis. Finally, we discuss the extension of this new pH-centric oncological paradigm into the opposite metabolic and homeostatic acid-base situation found in human neurodegenerative diseases (HNDDs), which opens novel concepts in the prevention and treatment of HNDDs through the utilization of a cohort of neural and non-neural derived hormones and human growth factors. (C) 2017 Elsevier Ltd. All rights reserved.

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