期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 45, 期 3, 页码 423-441出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X17500264
关键词
Plumbagin; Anticancer Activities; Molecular Mechanisms; Pharmaceutical Applications; Review
资金
- Macao Science and Technology Development Fund [096/2015/A3]
- University of Macau [MYRG2014-00033-ICMS-QRCM, MYRG2014-00051-ICMS-QRCM, MYRG2015-00171-ICMS-QRCM]
- National Natural Science Foundation of China [81403120]
- Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences [Z02063, Z184]
- China Academy of Chinese Medical Sciences [CX201606]
It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of apoptosis and autophagy, the disruption of the cell cycle, the inhibition of invasion and metastasis, and anti-angiogenesis. Plumbagin inhibits the growth of cancer cells mainly through the modulation of the signals of PI3K/Akt/mTOR, AMPK, Ras, and so on. The pharmaceutical applications of plumbagin combined with nanocarriers to achieve better therapeutic efficiency are discussed in this review Among them, liposomes, nanoparticles, microspheres, micelles, and nisosomes are used in cancer treatment. The anticancer study of plumbagin in vivo is also summarized in this review. On the whole, we aim to review the research progress of plumbagin both in pharmacological and pharmaceutical filed, which may provide some reference for further research of plumbagin.
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