期刊
CANCER BIOLOGY & THERAPY
卷 18, 期 3, 页码 142-151出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2017.1281497
关键词
Cell proliferation; metastasis; miR-320a; NSCLC; STAT3
类别
资金
- National Natural Science Foundation of China [31371321, 31440061, 81502536]
- Shandong Science and Technology Committee [2015GSF118073, ZR2016CL09, 2014HP004]
MicroRNAs play important roles in tumorigenesis of various types of cancers. MiR-320a can inhibits cell proliferation of some cancers, but the biologic roles of miR-320a in lung cancer need to be further studied. Here, we investigated the roles of miR-320a in suppressing the proliferation of lung adenocarcinoma cells. MiR-320a treatment was found to effectively suppress LTEP-a-2 and A549 cell proliferation, and induce more apoptotic cells with irradiation treatment compared with control treatment. Our results also showed that miR-320a, as a novel miRNA, directly regulated signal transducer and activator of transcription 3 (STAT3) and its signals, such as Bcl(-)2, Bax, and Caspase 3. The siRNA-inhibited STAT3 levels further proved its roles in regulating STAT3 signals. Moreover, miR-320a treatment effectively suppressed cancer cell growth in mice xenografts compared with controls, and significantly inhibited cell migration in vitro and in vivo. Our findings collectively demonstrated that miR-320a, by directly regulating STAT3 signals, not only suppressed cell proliferation and metastasis, but also enhanced irradiation-induced apoptosis of adenocarcinomia cells.
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