期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1862, 期 1, 页码 102-113出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.06.015
关键词
Mitochondria; Cardiolipin; Respiratory chain; Protein import; Mitochondrial dynamics
资金
- Deutsche Forschungsgemeinschaft [BE 4679/2-1]
- Sonderforschungsbereich [746 P22]
- Excellence Initiative of the German Federal and State Governments (BIOSS Centre for Biological Signalling Studies) [EXC 294]
Mitochondria contain two membranes: the outer and inner membrane. Whereas the outer membrane is particularly enriched in phospholipids, the inner membrane has an unusual high protein content and forms large invaginations termed cristae. The proper phospholipid composition of the membranes is crucial for mitochondrial functions. Phospholipids affect activity, biogenesis and stability of protein complexes including protein translocases and respiratory chain supercomplexes. Negatively charged phospholipids such as cardiolipin are important for the architecture of the membranes and recruit soluble factors to the membranes to support mitochondrial dynamics. Thus, phospholipids not only form the hydrophobic core of biological membranes that surround mitochondria, but also create a specific environment to promote functions of various protein machineries. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. (C) 2016 Elsevier B.V. All rights reserved.
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