期刊
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
卷 353, 期 1, 页码 76-81出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjms.2016.10.009
关键词
Erythropoietin; Nonhematopoietic; Tissue protection; Antiapoptosis; Hypoxia-inducible factor
Erythropoietin (EPO) is the main regulator of red blood cell production. Since the 1990s, EPO has been used for the treatment of anemia associated with end-stage renal failure and chemotherapy. The erythropoietin receptors were found on other organs such as the brain, spinal cord, heart and skin. In addition, it has been shown that many tissues produce and locally release EPO in response to hypoxic, biochemical and physical stress. In cellular, animal and clinical studies, EPO protects tissues from ischemia and reperfusion injury, has antiapoptotic effects and improves regeneration after injury. In this article, we mainly review the nonhematopoietic effects and new possible clinical indications for EPO.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据