期刊
CURRENT MEDICINAL CHEMISTRY
卷 24, 期 21, 页码 2261-2275出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170303161659
关键词
P2X7; ATP; autophagy; pyroptosis; IL-1 beta; NLRP3; Akt; VEGF
资金
- Italian Association for Cancer Research [AIRC IG16812]
- Region Emilia Romagna (Bando Alessandro Liberati)
- University of Ferrara
P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP) that attracted increasing attention for its role in immune reactions, neurobiology and oncology. As receptor for an extracellular ligand, P2X7 activates a series of intracellular signalling pathways mainly via alterations of the ion permeability, but also through formation of a large unselective pore and direct interaction with other proteins. Here we wish to give an overview on the main biochemical paths initiated by P2X7 activation by revising recent and established literature on P2X7-triggered signalling cascades leading to cell death, inflammatory and immune response activation, proliferation and metabolism modulation. We will focus on the well-known P2X7 inflammasome/NF-kB and pro-apoptotic networks but also cover P2X7-activated emerging autophagic, pyroptotic and proliferative-oncogenic pathways, like beclin-1/LC3-II, caspase-11, Akt and VEGF axes.
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