期刊
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
卷 34, 期 6, 页码 551-587出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevTherDrugCarrierSyst.2017020147
关键词
HIV prevention; pre-exposure prophylaxis (PrEP); transdermal delivery; chemical penetration enhancers; physical enhancement techniques
资金
- United States Agency for International Development (USAID) [MAPS2-15-061, AID-OAA-A-14-00010]
Constant efforts for HIV prevention using antiretroviral drugs, pre- and post-exposure prophylactic agents, and microbicides tire being made by researchers. Drug-delivery systems such as oral tablets and coitally dependent vaginal gels are short acting, require daily application, and are associated with user adherence issues, whereas the coitally independent systems such as injectables and biodegradable implants are long acting, lasting several months, during which time the termination of prophylaxis is impractical in case of adverse effects. An effective drug-delivery system to be used for an intermediate duration, if available, would be an attractive alternative option for users in terms of adherence. Transdermal delivery systems, overcoming most of the limitations of the other routes of administration and aiming to provide sustained delivery of drugs through skin, may be explored for HIV prevention. Passive and physical enhancement techniques may be designed strategically to improve the transdermal delivery of HIV preventive agents.
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