期刊
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
卷 27, 期 3, 页码 229-236出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevEukaryotGeneExpr.2017019712
关键词
Interleukin-6; insulin resistance; diabetes mellitus; pro-inflammatory cytokines
资金
- Higher Education Commission of Pakistan [21-1061/SRGP/RD/HEC/2016]
Interleukin-6 (IL-6) is a proinflammatory cytokine that decisively induces the development of insulin resistance and pathogenesis of type 2 diabetes mellitus (T2DM) through the generation of inflammation by controlling differentiation, migration, proliferation, and cell apoptosis. The presence of IL-6 in tissues is a normal consequence, but its irregular production and long-term exposure leads to the development of inflammation, which induces insulin resistance and overt T2DM. There is a mechanistic relationship between the stimulation of IL-6 and insulin resistance. IL-6 causes insulin resistance by impairing the phosphorylation of insulin receptor and insulin receptor substrate-1 by inducing the expression of SOCS-3, a potential inhibitor of insulin signaling. In this article, we have briefly described how IL-6 induces the insulin resistance and pathogenesis of T2DM. The prevention of inflammatory disorders by blocking IL-6 and IL-6 signaling may be an effective strategy for the treatment of insulin resistance and T2DM.
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