期刊
GUT MICROBES
卷 8, 期 6, 页码 521-543出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2017.1345414
关键词
cardiovascular disease; diabetes; gastrointestinal disease; infections; obesity; probiotics
The scientific literature has demonstrated that probiotics have a broad spectrum of activity, although often the results are contradictory. This study provides a critical overview of the current meta-analyses that have evaluated the efficacy of probiotics in physiologic and pathological conditions, such as metabolic disease, antibiotic-associated and Clostridium difficile-associated diarrhea, IBS, constipation, IBD, chemotherapy-associated diarrhea, respiratory tract infection, ventilator-associated pneumonia, NAFLD, liver encephalopathy, periodontitis, depression, vaginosis, urinary tract infections, pancreatitis, incidence of ventilator-associated pneumonia, hospital infection and stay in ICU, mortality of post-trauma patients, necrotising enterocolitis in premature infants. Only for antibiotic-and Clostridium difficile-associated diarrhea, and respiratory tract infections the effects of probiotics are considered evidence-based. Concerning other fields, meta-analyses lacks to define type and biologic effect of probiotic strains, as well as the outcome in a disease state. Therefore, the results presented should be a stimulus for further studies which will provide clinical recommendations.
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