期刊
CURRENT MEDICINAL CHEMISTRY
卷 24, 期 9, 页码 876-887出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867323666161202150008
关键词
Autophagy; bacteria; colon cancer; colitis; lactic acid bacteria; IBD; inflammation; probiotics; NF-kappa B; vitamin D; VDR
资金
- NIDDK [R01 DK105118]
- International Program for Ph.D. Candidates, Sun Yat-Sen University
Vitamin D is an important factor in regulating inflammation, immune responses, and carcinoma inhibition via action of its receptor, vitamin D receptor (VDR). Recent studies have demonstrated the role of vitamin D/VDR in regulating host-bacterial interactions. Probiotics are beneficial bacteria with the power of supporting or favoring life on the host. In the current review, we will discuss the recent progress on the roles of vitamin D/VDR in gut microbiome and inflammation. We will summarize evidence of probiotics in modulating vitamin D/VDR and balancing gut microbiota in health and gastrointestinal diseases. Moreover, we will review the clinical application of probiotics in prevention and therapy of IBD or colon cancer. Despite of the gains, there remain several barriers to advocate broad use of probiotics in clinical therapy. We will also discuss the limits and future direction in scientific understanding of probiotics, vitamin D/VDR, and host responses.
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