期刊
BIORESOURCES
卷 12, 期 2, 页码 2941-2954出版社
NORTH CAROLINA STATE UNIV DEPT WOOD & PAPER SCI
DOI: 10.15376/biores.12.2.2941-2954
关键词
Cellulose nanofiber; 3D Bioprinting; Gelatin methacrylamide; Hydrogel; Bioink
资金
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1D1A1A01056711]
- Ministry of Trade, Industry & Energy (MOTIE, Korea) [10062717]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10062717] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Inadequate rheological properties of gelatin methacrylamide (GelMA) were successfully improved by incorporating cellulose nanofibers (CNFs), such that the printed scaffolds could maintain their structural fidelity during the three-dimensional (3D) bio-printing process. The CNFs provided an outstanding shear thinning property, and the GelMA/CNF inks exhibited high zero shear viscosity and structural fidelity under a low dispensing pressure. After evaluating the printability, composite inks containing 2% w/v CNF were observed to have an optimal concentration of CNF to prepare 3D print stable constructs. Therefore, these inks were used to manufacture human nose and ear structures, producing highly porous structures in the printed composite hydrogels. Furthermore, the mechanical stability of the GelMA/CNF composite hydrogel was increased when CNFs were incorporated, which indicated that CNFs played an important role in enhancing the structural properties of the composite hydrogels. Additionally, the biocompatibility of CNF-reinforced hydrogels was evaluated using a fibroblast cell line.
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