相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth
Nicola Rath et al.
EMBO MOLECULAR MEDICINE (2017)
Differential activity of nonmuscle myosin II isoforms determines their localization at the cleavage furrow of megakaryocytes
A. Roy et al.
BLOOD (2016)
Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells
Valentin Magidson et al.
JOURNAL OF CELL BIOLOGY (2016)
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity
Abhishek Kumar et al.
JOURNAL OF CELL BIOLOGY (2016)
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
Sophia Frentzas et al.
NATURE MEDICINE (2016)
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
Hanane Laklai et al.
NATURE MEDICINE (2016)
Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases
Nuh N. Rahbari et al.
Science Translational Medicine (2016)
Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease
FuiBoon Kai et al.
TRENDS IN CELL BIOLOGY (2016)
Fibronectin protects lung cancer cells against docetaxel-induced apoptosis by promoting Src and caspase-8 phosphorylation
Sida Qin et al.
TUMOR BIOLOGY (2016)
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
Hadir Marei et al.
NATURE COMMUNICATIONS (2016)
Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src
Marco Perez et al.
ONCOTARGET (2016)
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue
Zahra Erami et al.
CELL REPORTS (2016)
Manufacture of patient-specific vascular replicas for endovascular simulation using fast, low-cost method
Naoki Kaneko et al.
SCIENTIFIC REPORTS (2016)
Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
Eishu Hirata et al.
CANCER CELL (2015)
Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Amine Sadok et al.
CANCER RESEARCH (2015)
Src/STAT3-dependent heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to doxorubicin by promoting autophagy
Qixing Tan et al.
CANCER SCIENCE (2015)
A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis
Jasreen Kular et al.
DEVELOPMENTAL CELL (2015)
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
Bryan W. Miller et al.
EMBO MOLECULAR MEDICINE (2015)
Final results of a phase Ib study of gemcitabine plus PEGPH20 in patients with stage IV previously untreated pancreatic cancer.
Sunil R. Hingorani et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors
Sandro Boland et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial
David Goldstein et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Tumour exosome integrins determine organotropic metastasis
Ayuko Hoshino et al.
NATURE (2015)
Whole genomes redefine the mutational landscape of pancreatic cancer
Nicola Waddell et al.
NATURE (2015)
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Bruno Costa-Silva et al.
NATURE CELL BIOLOGY (2015)
Drug repurposing in oncology-patient and health systems opportunities
Francesco Bertolini et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2015)
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients
Sara M. Tolaney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells
Lekhana Bhandary et al.
ONCOTARGET (2015)
Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity
Anna Johansson-Percival et al.
CELL REPORTS (2015)
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+CD11b+Myeloid-Derived Suppressor Cells
David Gallego-Ortega et al.
PLOS BIOLOGY (2015)
nab-Paclitaxel Plus Gemcitabine for Metastatic Pancreatic Cancer: Long-Term Survival From a Phase III Trial
David Goldstein et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
Berna C. Oezdemir et al.
CANCER CELL (2014)
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Andrew D. Rhim et al.
CANCER CELL (2014)
Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment
David Herrmann et al.
CARCINOGENESIS (2014)
Ripasudil: First Global Approval
Karly P. Garnock-Jones
DRUGS (2014)
The extracellular matrix modulates the hallmarks of cancer
Michael W. Pickup et al.
EMBO REPORTS (2014)
Targeting mTOR dependency in pancreatic cancer
Douglas C. Morran et al.
GUT (2014)
Seeds and Soil: Unraveling the Role of Local Tumor Stroma in Distant Metastasis
Dan G. Duda et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
Susanne Walz et al.
NATURE (2014)
FibrilTool, an ImageJ plug-in to quantify fibrillar structures in raw microscopy images
Arezki Boudaoud et al.
NATURE PROTOCOLS (2014)
Physical influences of the extracellular environment on cell migration
Guillaume Charras et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
John J. Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Imaging hallmarks of cancer in living mice
Saskia I. J. Ellenbroek et al.
NATURE REVIEWS CANCER (2014)
Developments in preclinical cancer imaging: innovating the discovery of therapeutics
James R. W. Conway et al.
NATURE REVIEWS CANCER (2014)
Mechanotransduction Pathways Promoting Tumor Progression Are Activated in Invasive Human Squamous Cell Carcinoma
S. Jan Ibbetson et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis (Publication with Expression of Concern. See vol. 79, pg. 5124, 2019)
Thomas R. Cox et al.
CANCER RESEARCH (2013)
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Michael A. Jacobetz et al.
GUT (2013)
Randomized phase II study of three doses of the integrin inhibitor cilengitide versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer
Christian Manegold et al.
INVESTIGATIONAL NEW DRUGS (2013)
Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension
Vivek Gupta et al.
JOURNAL OF CONTROLLED RELEASE (2013)
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Daniel D. Von Hoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo
Yoshinori Kagawa et al.
PLOS ONE (2013)
Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
Paolo P. Provenzano et al.
CANCER CELL (2012)
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
Nicola Rath et al.
EMBO REPORTS (2012)
Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage
Guang Jian Liu et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Advancing cancer drug discovery towards more agile development of targeted combination therapies
Neil O. Carragher et al.
FUTURE MEDICINAL CHEMISTRY (2012)
The extracellular matrix: A dynamic niche in cancer progression
Pengfei Lu et al.
JOURNAL OF CELL BIOLOGY (2012)
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Andrew V. Biankin et al.
NATURE (2012)
Resistance to Fluid Shear Stress Is a Conserved Biophysical Property of Malignant Cells
J. Matthew Barnes et al.
PLOS ONE (2012)
Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis
Laila Ritsma et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Cancer invasion and resistance: interconnected processes of disease progression and therapy failure
Stephanie Alexander et al.
TRENDS IN MOLECULAR MEDICINE (2012)
Targeting Src family kinases in anti-cancer therapies: turning promise into triumph
Siyuan Zhang et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
Victoria Sanz-Moreno et al.
CANCER CELL (2011)
Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
Michael S. Samuel et al.
CANCER CELL (2011)
Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
Paul Timpson et al.
CANCER RESEARCH (2011)
Stromal biology and therapy in pancreatic cancer
Albrecht Neesse et al.
GUT (2011)
Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis
Alyssa L. Kennedy et al.
MOLECULAR CELL (2011)
The physics of cancer: the role of physical interactions and mechanical forces in metastasis
Denis Wirtz et al.
NATURE REVIEWS CANCER (2011)
Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis
Olivier Gavet et al.
DEVELOPMENTAL CELL (2010)
Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma
Jennifer P. Morton et al.
GASTROENTEROLOGY (2010)
Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy
Riccardo Cicchi et al.
JOURNAL OF BIOPHOTONICS (2010)
Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis
Olivier Gavet et al.
JOURNAL OF CELL BIOLOGY (2010)
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells
Rebecca W. Scott et al.
JOURNAL OF CELL BIOLOGY (2010)
Pancreatic Cancer
Manuel Hidalgo
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
Jennifer P. Morton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche
Janine T. Erler et al.
CANCER CELL (2009)
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental et al.
CELL (2009)
The actin cytoskeleton in cancer cell motility
Michael F. Olson et al.
CLINICAL & EXPERIMENTAL METASTASIS (2009)
Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments
Zhenye Yang et al.
JOURNAL OF CELL BIOLOGY (2009)
Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit
Michael E. Bekier et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive et al.
SCIENCE (2009)
The metastatic niche: adapting the foreign soil
Bethan Psaila et al.
NATURE REVIEWS CANCER (2009)
ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epithelial tumor cells
Robert Torka et al.
EXPERIMENTAL CELL RESEARCH (2006)
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
Lyubomir T. Vassilev et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Quantifying collagen type in mature burn scars: A novel approach using histology and digital image analysis
JM Rawlins et al.
JOURNAL OF BURN CARE & RESEARCH (2006)
Efficacy and safety of fasudil in patients with stable angina - A double-blind, placebo-controlled, phase 2 trial
RM Vicari et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)
Tensional homeostasis and the malignant phenotype
MJ Paszek et al.
CANCER CELL (2005)
Trp53R172H and KraSG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
SR Hingorani et al.
CANCER CELL (2005)
Visualizing the mechanical activation of Src
YX Wang et al.
NATURE (2005)
Aurora-B and Rho-kinase/ROCK, the two cleavage furrow kinases, independently regulate the progression of cytokinesis: possible existence of a novel cleavage furrow kinase phosphorylates ezrin/radixin/moesin (ERM)
T Yokoyama et al.
GENES TO CELLS (2005)
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
SR Hingorani et al.
CANCER CELL (2003)
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
E Sahai et al.
NATURE CELL BIOLOGY (2003)
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
B Wojciak-Stothard et al.
JOURNAL OF CELL BIOLOGY (2003)
Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe
M Castedo et al.
CELL DEATH AND DIFFERENTIATION (2002)
Taking cell-matrix adhesions to the third dimension
E Cukierman et al.
SCIENCE (2001)
Histone H3 phosphorylation and cell division
F Hans et al.
ONCOGENE (2001)
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow
H Kosako et al.
ONCOGENE (2000)
分享论文
