期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1864, 期 1, 页码 125-137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2016.10.019
关键词
Mitochondrial protein biogenesis; Protein transport; Retrograde signaling; UPRmt; UPRam
资金
- Ministerial funds for science within Ideas Plus program [000263]
- National Science Centre, Poland [2015/18/A/NZ1/00025, 2015/19/B/NZ3/03272, 2016/20/S/NZ1/00423]
Mitochondria are central power stations in the cell, which additionally serve as metabolic hubs for a plethora of anabolic and catabolic processes. The sustained function of mitochondria requires the precisely controlled biogenesis and expression coordination of proteins that originate from the nuclear and mitochondrial genomes. Accuracy of targeting, transport and assembly of mitochondrial proteins is also needed to avoid deleterious effects on protein homeostasis in the cell. Checkpoints of mitochondrial protein transport can serve as signals that provide information about the functional status of the organelles. In this review, we summarize recent advances in our understanding of mitochondrial protein transport and discuss examples that involve communication with the nucleus and cytosol. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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