期刊
CHINESE JOURNAL OF CHEMISTRY
卷 36, 期 1, 页码 42-46出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201700534
关键词
rosamine; phenolate and phenol; protonation and deprotonation; pH probe; mitochondria biomarker
资金
- National Natural Science Foundation of China [51273136]
- Natural Science Fund of Jiangsu Province [BK20151262]
- the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Project of Scientific and Technologic Infrastructure of Suzhou [SZS201708]
- Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions
Two rosamine-based pH probes 1a and 1b with pyronine-phenol skeleton were designed and synthesized by a simple one-step reaction. pH titration experiments showed that probes 1a and 1b exhibit near OFF-ON fluorescence responses around 550-750 nm towards the hydrogen ions. The pK(a) of the probe 1a is 8.29, while that of the probe 1b increases to 12.1 because of the hydrogen bond inside it. Selective and competitive experiments indicated that both common ions and amino acids did not interfere their emission with hydrogen ions. Moreover, confocal fluorescent imaging showed that the probe 1a could be served as mitochondria biomarker in HeLa and Ges-1 cells.
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