期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 592, 期 -, 页码 357-365出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2017.03.035
关键词
Bisphenol S; Immunotoxicity; Metabolomics; Lipidomics; LC-MS/MS; Pro-inflammation
资金
- National Natural Science Foundation of China [21507106, 91543202]
- Hong Kong Research Grants Council-General Research Fund [1230195]
- Hong Kong Baptist University Strategic Development Fund [15-1012-P04]
As an important structural analogue of bisphenol A (BPA), bisphenol S (BPS) has been used as alternatives to BPA in industrialized production. However, the immunotoxicity of BPS remains poorly understood. As a critical model in inflammatory responses, macrophages are used to explore the immunotoxic potential and mechanisms of BPS at environmentally relevant concentrations in our study. Here, we are combining molecular toxicology andmass spectrometry (MS)-based global metabolomics and lipidomics study together to estimate the variation of cytokines profiling and metabolism characteristic following BPS exposure. Our results demonstrated that BPS exposure induced pro-inflammatory phenotype by activating the immuno-related cytokines which include TNF-alpha, IL-1 beta and IL-6, modulatingmetabolic pathways which include glycolytic, glutathione (GSH), sphingomyelin (SM)ceramide (Cer), glycerophospholipids (GPs) and glycerolipids (GLs). These toxicological mechanisms are providing us with a deeper understanding of the critical role of metabolites and lipids reprogramming in immunotoxicity of BPS. (C) 2017 Elsevier B.V. All rights reserved.
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