期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 1, 页码 236-240出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710273
关键词
analytical methods; cell adhesion; intracellular metabolites; live single-cell extraction; microfluidic chips
资金
- National Key R&D Program of China [2017YFC0906800]
- National Natural Science Foundation of China [214350002, 81373373, 21621003]
Single-cell biology provides insights into some of the most fundamental processes in biology and promotes the understanding of life's mysteries. As the technologies to study single-cells expand, they will require sophisticated analytical tools to make sense of various behaviors and components of single-cells as well as their relations in the adherent tissue culture. In this paper, we revealed cell heterogeneity and uncovered the connections between cell adhesion strength and cell viability at single-cell resolution by extracting single adherent cells of interest from a standard tissue culture by using a microfluidic chip-based live single-cell extractor (LSCE). We believe that this method will provide a valuable new tool for single-cell biology.
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