4.7 Review

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Hypoxia induces heart regeneration in adult mice

Yuji Nakada et al.

NATURE (2017)

Review Oncology

Common pitfalls in preclinical cancer target validation

William G. Kaelin

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

L. Zhou et al.

ONCOGENE (2016)

Article Biochemistry & Molecular Biology

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

Benjamin A. Olenchock et al.

Article Biochemistry & Molecular Biology

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

David Clever et al.

Article Multidisciplinary Sciences

Targeting renal cell carcinoma with a HIF-2 antagonist

Wenfang Chen et al.

NATURE (2016)

Article Multidisciplinary Sciences

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Hyejin Cho et al.

NATURE (2016)

Article Multidisciplinary Sciences

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth

Michael S. Nakazawa et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Reprogramming the immunological microenvironment through radiation and targeting Axl

Todd A. Aguilera et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness andmetastasis

Chris D. Madsen et al.

EMBO REPORTS (2015)

Article Multidisciplinary Sciences

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Thomas R. Cox et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

HIF-1 Signaling in Drug Resistance to Chemotherapy

N. A. Warfel et al.

CURRENT MEDICINAL CHEMISTRY (2014)

Article Medicine, Research & Experimental

Transport properties of pancreatic cancer describe gemcitabine delivery and response

Eugene J. Koay et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Nina Schoenhuber et al.

NATURE MEDICINE (2014)

Article Biotechnology & Applied Microbiology

Tackling the cancer stem cells - what challenges do they pose?

Diwakar R. Pattabiraman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Multidisciplinary Sciences

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

Erinn B. Rankin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

被撤回的出版物: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (Retracted article. See vol. 119, 2022)

Debangshu Samanta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

PHD Inhibition Mitigates and Protects Against Radiation-Induced Gastrointestinal Toxicity via HIF2

Cullen M. Taniguchi et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Multidisciplinary Sciences

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Anne-Theres Henze et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

PHD3 regulates EGFR internalization and signalling in tumours

Boyan K. Garvalov et al.

NATURE COMMUNICATIONS (2014)

Article Oncology

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

Daniele M. Gilkes et al.

CANCER RESEARCH (2013)

Article Biochemistry & Molecular Biology

A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition

Kevin Wei et al.

NATURE MEDICINE (2013)

Article Oncology

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

Cristina Branco-Price et al.

CANCER CELL (2012)

Article Oncology

Loss of Fibroblast HIF-1α Accelerates Tumorigenesis

Jung-whan Kim et al.

CANCER RESEARCH (2012)

Article Gastroenterology & Hepatology

Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

Bharath Nath et al.

HEPATOLOGY (2012)

Review Endocrinology & Metabolism

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

Saravanan S. Karuppagounder et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Medicine, Research & Experimental

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

Nicolas Skuli et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Gastroenterology & Hepatology

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

Mert Erkan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

Article Biochemistry & Molecular Biology

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Eric V. Dang et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Biochemistry & Molecular Biology

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

Minna Heikkila et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Article Multidisciplinary Sciences

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene et al.

NATURE (2011)

Review Oncology

PHD2 in tumour angiogenesis

D. A. Chan et al.

BRITISH JOURNAL OF CANCER (2010)

Article Cell Biology

The extracellular matrix at a glance

Christian Frantz et al.

JOURNAL OF CELL SCIENCE (2010)

Article Medicine, Research & Experimental

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Hongxia Z. Imtiyaz et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Review Gastroenterology & Hepatology

Hypoxia: an alarm signal during intestinal inflammation

Sean P. Colgan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Review Biochemistry & Molecular Biology

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

G. L. Semenza

ONCOGENE (2010)

Article Multidisciplinary Sciences

HIF-2α deletion promotes Kras-driven lung tumor development

Jolly Mazumdar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Medicine, Research & Experimental

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

William Y. Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Biotechnology & Applied Microbiology

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Peter Fraisl et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Biochemistry & Molecular Biology

Biology of hypoxia-inducible factor-2 alpha in development and disease

S. A. Patel et al.

CELL DEATH AND DIFFERENTIATION (2008)

Article Biochemistry & Molecular Biology

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

Tammie Bishop et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Biochemistry & Molecular Biology

The tumor microenvironment and its role in promoting tumor growth

T. L. Whiteside

ONCOGENE (2008)

Review Genetics & Heredity

Harnessing hypoxic adaptation to prevent, treat, and repair stroke

Rajiv R. Ratan et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2007)

Review Biochemistry & Molecular Biology

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1

Gregg L. Semenza

BIOCHEMICAL JOURNAL (2007)

Review Oncology

Hypoxia: A key regulator of angiogenesis in cancer

Debbie Liao et al.

CANCER AND METASTASIS REVIEWS (2007)

Review Medicine, Research & Experimental

Oxygen, oxidative stress, hypoxia, and heart failure

FJ Giordano

JOURNAL OF CLINICAL INVESTIGATION (2005)

Review Medicine, General & Internal

von Hippel-Lindau disease

RR Lonser et al.

LANCET (2003)

Review Biochemistry & Molecular Biology

Regulation of angiogenesis by hypoxia: role of the HIF system

CW Pugh et al.

NATURE MEDICINE (2003)

Article Biochemistry & Molecular Biology

The role of iron and 2-oxoglutarate oxygenases in signalling

KS Hewitson et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2003)

Review Biochemistry & Molecular Biology

Hypoxia-inducible factor and its biomedical relevance

LE Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

HIF-1α is essential for myeloid cell-mediated inflammation

T Cramer et al.

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia

N Goda et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Chemistry, Medicinal

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

LA McNeill et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)

Article Multidisciplinary Sciences

A conserved family of prolyl-4-hydroxylases that modify HIF

RK Bruick et al.

SCIENCE (2001)