期刊
SCIENCE
卷 355, 期 6322, 页码 287-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal2541
关键词
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资金
- Gatsby Charitable Foundation
- European Research Council
- Austrian Academy of Science through the Gregor Mendel Institute
- Deutsche Forschungsgemeinschaft [STE 2448/1]
- European Molecular Biology Organization
- U.K. Biotechnology and Biological Sciences Research Council [ALTF 459-2011, BB/M013499]
- Erasmus Mundus program
- BBSRC [BBS/E/J/000PR9796, BBS/E/J/000PR9795] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000PR9796, BBS/E/J/000PR9795] Funding Source: researchfish
In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold that modulates receptor kinase complex assembly. A similar scaffolding mechanism may underlie FER function in other signaling pathways.
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