期刊
SCIENCE
卷 356, 期 6342, 页码 1059-1063出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aam9041
关键词
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资金
- Carlsberg Foundation
- Leverhulme Trust
- China Scholarship Council
- Max Planck Society
- Max-Planck-Institut fur Kohlenforschung
- Otto Rohm Gedachtnisstiftung
- Fonds der Chemischen Industrie
Compounds bearing aryl-sulfur and aryl-phosphorus bonds have found numerous applications in drug development, organic materials, polymer science, and homogeneous catalysis. We describe palladium-catalyzed metathesis reactions of both compound classes, each of which proceeds through a reversible arylation manifold. The synthetic power and immediate utility of this approach are demonstrated in several applications that would be challenging to achieve by means of traditional cross-coupling methods. The C(sp(2))-S bond metathesis protocol was used in the depolymerization of a commercial thermoplastic polymer and in the late-stage derivatization of a drug. The C(sp(2))-P variant led to the convenient preparation of a variety of phosphorus heterocycles, including a potential chiral ligand and fluorescent organic materials, via a ring-closing transformation.
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