期刊
SCIENCE
卷 356, 期 6343, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal4713
关键词
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资金
- ATIP/Avenir Program
- Gustave Roussy Institute
- INSERM
- Ligue Nationale Contre le Cancer
- Agence Nationale de la Recherche [ANR-15-CE15-0005-03, ANR-14-CE12-0001-01]
- Agence Nationale de la Recherche (ANR) [ANR-15-CE15-0005] Funding Source: Agence Nationale de la Recherche (ANR)
Migrating cells often use focal adhesions in order to move. Focal adhesions are less prominent in cells migrating in three-dimensional (3D) as compared with 2D environments. We looked for alternative adhesion structures supporting cell migration. We analyzed the dynamics of clathrin-coated pits in cells migrating in a 3D environment of collagen fibers. Both topological cues and local engagement of integrins triggered the accumulation of clathrin-coated structures on fibers. Clathrin/adaptor protein 2 (AP-2) lattices pinched collagen fibers by adopting a tube-like morphology and regulated adhesion to fibers in an endocytosis-independent manner. During migration, tubular clathrin/AP-2 lattices stabilized cellular protrusions by providing anchoring points to collagen fibers. Thus, tubular clathrin/AP-2 lattices promote cell adhesion that, in coordination with focal adhesions, supports cell migration in 3D.
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