期刊
SCIENCE
卷 355, 期 6326, 页码 739-743出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aak9973
关键词
-
资金
- NIH [GM113172, GM51986, DP2AI117923-01]
- Newcastle University Research Fellowship
- Royal Society [RG150475]
- Science Without Borders Research Fellowship
- European Research Council [SynDiv 669598]
- NSF Graduate Research Fellowship Program [DGE1144152]
- [S10RR028697-01]
The mechanism by which bacteria divide is not well understood. Cell division is mediated by filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to the division site. To understand how these components coordinate to divide cells, we visualized their movements relative to the dynamics of cell wall synthesis during cytokinesis. We found that the division septum was built at discrete sites that moved around the division plane. FtsAZ filaments treadmilled circumferentially around the division ring and drove the motions of the peptidoglycan-synthesizing enzymes. The FtsZ treadmilling rate controlled both the rate of peptidoglycan synthesis and cell division. Thus, FtsZ treadmilling guides the progressive insertion of new cell wall by building increasingly smaller concentric rings of peptidoglycan to divide the cell.
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