期刊
SCIENCE
卷 357, 期 6351, 页码 596-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aan3458
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资金
- Connecticut Mental Health Center (CMHC)
- Connecticut State Department of Mental Health and Addiction Services (DMHAS)
- International Mental Health Research Organization/Janssen Rising Star Translational Research Award
- National Institute of Mental Health (NIMH) [5R01MH067073-09]
- Clinical and Translational Science Award grant from the National Center for Research Resources (NCRR) [UL1 TR000142]
- National Center for Advancing Translational Science (NCATS), components of the National Institutes of Health (NIH)
- NIH roadmap for Medical Research
- Clinical Neurosciences Division of the U.S. Department of Veterans Affairs
- National Center for Post-Traumatic Stress Disorders
- VA Connecticut Healthcare System (VACHS), West Haven, CT, USA
- Integrated Mentored Patient-Oriented Research Training (IMPORT) in Psychiatry grant [5R25MH071584-07]
- Clinical Neuroscience Research Training in Psychiatry grant from NIMH [5T32MH19961-14]
- VA Schizophrenia Research Special Fellowship from VACHS, West Haven, CT, USA
- Yale Detre Fellowship for Translational Neuroscience
- Brain and Behavior Research Foundation in the form of a National Alliance for Research on Schizophrenia and Depression Young Investigator Award
Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without.
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