期刊
SCIENCE
卷 355, 期 6323, 页码 398-402出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal2690
关键词
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资金
- CREST program of JST
- Japan Society for the Promotion of Science KAKENHI grant [JP23220009, JP23650208, JP25293136, JP25430015, JP25860429, JP15K19194, 15K18344, JP25115002, JP26115523, JP15H01295, S1311009]
- Mitsubishi Foundation
- Uehara Memorial Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [16H04653, 15H01295, 15K18344, 25430015, 25115002, 17H04062, 25293136, 25293093, 16K07004] Funding Source: KAKEN
Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.
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