期刊
SCIENCE
卷 355, 期 6330, 页码 1147-1152出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aam7304
关键词
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资金
- National Health and Medical Research Council of Australia
- Cancer Council Victoria
- Snowdome Foundation
- Celgene
- Pfizer
Cancer biology is profoundly influenced by changes in the epigenome. Because the dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past few years have witnessed an unprecedented investment in the development, characterization, and translation of targeted epigenetic therapies. In this review, I provide a broad context for recent developments that offer a greater understanding of how epigenetic regulators facilitate the initiation, maintenance, and evolution of cancer. I discuss newly developed epigenetic therapies and the cellular and molecular mechanisms that may govern sensitivity and resistance to these agents. I also review the rationale for future combination therapies involving existing and emerging epigenetic drugs.
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