期刊
SCIENCE
卷 355, 期 6332, 页码 1411-1415出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aai7984
关键词
-
资金
- Howard Hughes Medical Institute
- NIH [HL70029, HL40959]
- NIH Medical Scientist Training Program
Slow, controlled breathing has been used for centuries to promote mental calming, and it is used clinically to suppress excessive arousal such as panic attacks. However, the physiological and neural basis of the relationship between breathing and higher-order brain activity is unknown. We found a neuronal subpopulation in the mouse preBotzinger complex (preBotC), the primary breathing rhythm generator, which regulates the balance between calm and arousal behaviors. Conditional, bilateral genetic ablation of the similar to 175 Cdh9/Dbx1 double-positive preBotC neurons in adult mice left breathing intact but increased calm behaviors and decreased time in aroused states. These neurons project to, synapse on, and positively regulate noradrenergic neurons in the locus coeruleus, a brain center implicated in attention, arousal, and panic that projects throughout the brain.
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