期刊
SCIENCE
卷 356, 期 6338, 页码 638-641出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aah4204
关键词
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资金
- San Diego Center for Systems Biology (NIH) [P50 GM085764]
- National Institute of General Medical Sciences [R01 GM121888]
- Defense Advanced Research Projects Agency [HR0011-16-2-0035]
- Howard Hughes Medical Institute-Simons Foundation Facility Scholars program
- Simons Foundation Fellowship of the Helen Hay Whitney Foundation
- Burroughs Wellcome Fund
- Spanish Ministry of Economy and Competitiveness
- FEDER (European, Regional Development Fund) [FIS2015-66503-C3-1-P]
- Generalitat Catalunya [2014SGR0947]
- ICREA (Catalan Institution for Research and Advanced Studies) Academia program
- Maria de Maeztu Programme for Units of Excellence in Research and Development (Spanish Ministry of Economy and Competitiveness) [MOM-2014-0370]
- La Caixa foundation
- Formacion del Profesorado Universtario program of the Ministerio de Educacion, Cultura y Deportes, Spain
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1450867] Funding Source: National Science Foundation
Bacteria within communities can interact to organize their behavior. It has been unclear whether such interactions can extend beyond a single community to coordinate the behavior of distant populations. We discovered that two Bacillus subtilis biofilm communities undergoing metabolic oscillations can become coupled through electrical signaling and synchronize their growth dynamics. Coupling increases competition by also synchronizing demand for limited nutrients. As predicted by mathematical modeling, we confirm that biofilms resolve this conflict by switching from in-phase to antiphase oscillations. This results in time-sharing behavior, where each community takes turns consuming nutrients. Time-sharing enables biofilms to counterintuitively increase growth under reduced nutrient supply. Distant biofilms can thus coordinate their behavior to resolve nutrient competition through time-sharing, a strategy used in engineered systems to allocate limited resources.
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