期刊
BIOINFORMATICS
卷 34, 期 1, 页码 117-119出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btx580
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资金
- Office for the Advancement of Research and Scholarship (OARS)
- Biology Department, Miami University, Oxford, Ohio, USA
CRISPR-Cas systems have been successfully applied in genome editing. Recently, the CRISPR-C2c2 system has been reported as a tool for RNA editing. Here we describe CRISPR-RT (CRISPR RNA-Targeting), the first web application to help biologists design crRNAs with improved target specificity for the CRISPR-C2c2 system. CRISPR-RT allows users to set up a wide range of parameters, making it highly flexible for current and future research in CRISPR-based RNA editing. CRISPR-RT covers major model organisms and can be easily extended to cover other species. CRISPR-RT will empower researchers in RNA editing. Availability and implementation: Freely available at http://bioinfolab.miamioh.edu/CRISPR-RT. Contact: liangc@miamioh.edu Supplementary information: Supplementary data are available at Bioinformatics online.
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