期刊
SCIENCE
卷 358, 期 6361, 页码 359-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aan4526
关键词
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资金
- Uehara Memorial Foundation
- Takeda Science Foundation
- Mitsubishi Foundation
- Core Research for Evolutionary Medical Science and Technology
- Leading Advanced Projects for Medical Innovation
- program of the Japan Agency for Medical Research and Development
- U.S. NIH [DK043351, DK92405]
- Helmsley Charitable Trust
- Crohn's & Colitis Foundation
- Public Health Service [R37 HL079142]
- Grants-in-Aid for Scientific Research [17K07477, 16K15293, 15H05657] Funding Source: KAKEN
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (T(H)1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.
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