期刊
SCIENCE
卷 355, 期 6321, 页码 184-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aag2787
关键词
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资金
- European Research Council [281511]
- European Research Council (ERC) [281511] Funding Source: European Research Council (ERC)
The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places. We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components.
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