期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 103, 期 2, 页码 243-252出版社
WILEY
DOI: 10.1002/cpt.915
关键词
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资金
- United States National Institutes of Health [U19 GM61388, P50 CA116201, U54 GM114838, R01 GM28157, R01 CA196648, U10 CA180868, UO1 CA18967]
- Breast Cancer Research Foundation
- Nan Sawyer Breast Cancer Fund
- Eisenberg Foundation
Biomedical research is undergoing rapid change, with the development of a series of analytical omics techniques that are capable of generating Biomedical Big Data. These developments provide an unprecedented opportunity to gain novel insight into disease pathophysiology and mechanisms of drug action and responsebut they also present significant challenges. Pharmacogenomics is a discipline within Clinical Pharmacology that has been at the forefront in defining, taking advantage of, and dealing with the opportunities and challenges of this aspect of the Post-Genome Project world. This overview will describe the evolution of germline pharmacogenomic research strategies as we have moved from an era of candidate genes to agnostic genome-wide association studies (GWAS) coupled with the functional and mechanistic pursuit of GWAS signals. Germline pharmacogenomic studies of breast cancer endocrine therapy will be used to illustrate research strategies that are being applied broadly to omics studies of drug response phenotypes.
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