期刊
BRITISH JOURNAL OF CANCER
卷 118, 期 1, 页码 117-120出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2017.351
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资金
- Danish Childhood Cancer Foundation [2014-50]
- Arvid Nilsson Foundation
- Danish Cancer Research Foundation
Background: Maternal diabetes may be linked to childhood acute lymphoblastic leukaemia (ALL) in the offspring. Methods: We assessed the association between maternal pregestational or gestational diabetes and offspring risk of childhood ALL in a register-based study, including all singletons born in Denmark during 1996-2015 (n=1 187 482). Results: Adjusted hazard ratios of childhood ALL were 2.91 (95% confidence interval (CI): 1.30-6.51) for maternal pregestational diabetes and 1.75 (95% CI: 1.02-2.98) for maternal gestational diabetes. Paternal diabetes did not alter offspring ALL risk, and we found no association between offspring ALL and later maternal risk of diabetes. Conclusions: Regardless that absolute ALL risk among offspring of women with diabetes remains low, our findings suggest that characteristics of the diabetic intrauterine environment promote ALL development. This offers a setting for future research into the biological mechanisms underlying childhood ALL.
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