期刊
SCIENCE
卷 356, 期 6341, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal3345
关键词
-
资金
- Jane Coffin Childs Memorial Fund for Medical Research
- Howard Hughes Medical Institute
- U.S. Geological Survey through the Wildlife Program of the Ecosystems Mission Area
- Gruss-Lipper postdoctoral fellowship from the EGL Charitable Foundation
- FONDECYT [11130305]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
We have a limited understanding of the genetic and molecular basis of evolutionary changes in the size and proportion of limbs. We studied wing and pectoral skeleton reduction leading to flightlessness in the Galapagos cormorant (Phalacrocorax harrisi). We sequenced and de novo assembled the genomes of four cormorant species and applied a predictive and comparative genomics approach to find candidate variants that may have contributed to the evolution of flightlessness. These analyses and cross-species experiments in Caenorhabditis elegans and in chondrogenic cell lines implicated variants in genes necessary for transcriptional regulation and function of the primary cilium. Cilia are essential for Hedgehog signaling, and humans affected by skeletal ciliopathies suffer from premature bone growth arrest, mirroring skeletal features associated with loss of flight.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据