期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 24, 期 3, 页码 690-698出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201704403
关键词
chirality; DNA; high-order structures; planarity; ruthenium
资金
- National Science Foundation of China [21471164, 21525105]
- 973 program [2015CB856301]
- Fundamental Research Funds for the Central Universities
In this work, it was found that DNA can undergo B-Z transformational changes and compaction in the presence of DNA intercalators such as ruthenium(II) polypyridyl complexes. The link between B-Z transition and condensation is weak but can be strengthened under certain circumstances with slight alterations to the structures of the ruthenium(II) complexes. Here, following on from previous research, this work reports a series of ruthenium(II) complexes with imidazophenanthroline ligands, which vary in size and planarity. The complexes exhibit distinct effects on DNA structures, ranging from little impact to the transformation of DNA secondary structures to the formation of higher-order DNA structures. Further studies on DNA morphological changes induced by chiral ruthenium(II) complexes are observed by atomic force microscopy and transmission electron microscopy.
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