GPR120 is not required for ω-3 PUFAs-induced cell growth inhibition and apoptosis in breast cancer cells

Intake of omega-3 PUFAs reduces the frequency of breast cancer, and GPR120 receptor transduces omega-3 PUFAs signaling to increase insulin sensitivity in mice, but whether GPR120 mediates omega-3 PUFAs signaling to inhibit breast carcinogenesis is currently unknown. In the present study, we found that GPR120 is highly expressed in human breast cancerous tissues but not adjacent normal tissue. Knockdown of GPR120 by siRNA in breast cancer cells significantly reduced cell growth, and dramatically increased omega-3 FFA-induced cell growth inhibition and apoptosis. Thus, these observations indicated that GPR120 promotes breast cancer cell growth, whereas omega-3 PUFA-induce breast cancer cell apoptosis independently of GPR120.