期刊
SCIENCE
卷 356, 期 6345, 页码 1383-1385出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aal3839
关键词
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资金
- NIH National Institute of Neurological Disorders and Stroke (NINDS) [NS053884]
- NIH NINDS [NS074039]
- New York State Stem Cell Science [C024287]
- Leona M. and Harry B. Helmsley Charitable Trust
- NIH NINDS fellowship [F31NS089252]
- Jerry and Emily Spiegel Laboratory for Cell Replacement Therapies
- University of Basel
Neural stem cells (NSCs) in specialized niches in the adult mammalian brain generate neurons throughout life. NSCs in the adult mouse ventricular-subventricular zone (V-SVZ) exhibit a regional identity and, depending on their location, generate distinct olfactory bulb interneuron subtypes. Here, we show that the hypothalamus, a brain area regulating physiological states, provides long-range regionalized input to the V-SVZ niche and can regulate specific NSC subpopulations. Hypothalamic proopiomelanocortin neurons selectively innervate the anterior ventral V-SVZ and promote the proliferation of Nkx2.1(+) NSCs and the generation of deep granule neurons. Accordingly, hunger and satiety regulate adult neurogenesis by modulating the activity of this hypothalamic-V-SVZ connection. Our findings reveal that neural circuitry, via mosaic innervation of the V-SVZ, can recruit distinct NSC pools, allowing on-demand neurogenesis in response to physiology and environmental signals.
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