期刊
SCIENCE
卷 358, 期 6366, 页码 1027-1032出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aan3456
关键词
-
资金
- NIH [MH109904, MH106874, AG048918, DK111178, NS092988]
- Kavli Foundation
- James S. McDonnell Foundation
- NSF [BCS-1316829]
- MINECO [BFU2014-55090-P]
- Howard Hughes International Early Career
- Secretaria d'Universitats i Recerca del Department d'Economia i Coneixement de la Generalitat de Catalunya
- [MH103339]
- [MH106934]
- [MH110926]
To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type-specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.
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