期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 3, 期 1, 页码 97-109出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2017.09.005
关键词
diffusion tensor MRI; exosomes; fiber architecture; regeneration; myocardial infarction
资金
- NHLBI NIH HHS [R01 HL151704] Funding Source: Medline
- NIBIB NIH HHS [R21 EB024701] Funding Source: Medline
The object of the study was to reveal the fiber microstructural response with diffusion tensor cardiac magnetic resonance after intramyocardial exosomes secreted by cardiosphere-derived cells (CDCEXO) in chronic porcine myocardial infarction. Porcine with myocardial infarction underwent intramyocardial delivery of human CDCEXO and placebo in a randomized placebo-controlled study. Four weeks after injection, viability improved in the CDCEXO group, whereas myocardial fiber architecture and cardiac function were preserved. in the placebo group, fiber architecture and cardiac function declined. Myocardial regeneration by CDCEXO is not tumor-like; instead, details of tissue architecture are faithfully preserved, which may foster physiological excitation and contraction. (C) 2018 Published by Elsevier on behalf of the The Authors.
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