期刊
SCHIZOPHRENIA RESEARCH
卷 200, 期 -, 页码 20-25出版社
ELSEVIER
DOI: 10.1016/j.schres.2017.09.013
关键词
Catatonia; Schizophrenia; Psychosis; Mood disorders; Familiality; Heritability
类别
资金
- Department of Health of the Government of Navarra [14/2010]
- Ministerio de Educacion y Ciencia [SAF2008-05674-C03-01-02]
- Comissionat per a Universitats I Recerca del DIUE [2009SGR827]
- Instituto de Salud Carlos III [PI/6//02148]
Background: This study examines the familial aggregation (familiality) of different phenotypic definitions of catatonia in a sample of multiplex families with psychotic and mood disorders. Methods: Participants were probands with a lifetime diagnosis of a DSM-IV functional psychotic disorder, their parents and at least one first-degree relative with a psychotic disorder. The study sample included 441 families comprising 2703 subjects, of whom 1094 were affected and 1609 unaffected. Familiality (h(2)) was estimated by linear mixed models using family membership as a random effect, with h(2) indicating the portion of phenotypic variance accounted for by family membership. Results: Familiality estimates highly varied for individual catatonia signs (h(2) = 0.17-0.65), principal component analysis-derived factors (h(2) = 029-0.49), number of catatonia signs present (h(2) = 0.03-0.43) and severity of the catatonia syndrome (h(2) = 025-0.59). Phenotypes maximizing familiality estimates included individual signs (mutism and rigidity, both h(2) = 0.65), presence of >= 5 catatonia signs (h(2) = 0.43), a classical catatonia factor (h(2) = 0.49), a DSM-IV catatonia syndrome at a severity level of moderate or higher (h(2) =059) and the diagnostic construct of psychosis with prominent catatonia features (h(2) =0.56). Familiality estimates of a DSM-lV catatonia syndrome did not significantly differ across the diagnostic categories of psychotic and mood disorders (h(2) =0.40-0.47). Conclusions: The way in which catatonia is defined has a strong impact on familiality estimates with some catatonia phenotypes exhibiting substantial familial aggregation, which may inform about the most adequate phenotypes for molecular studies. From a familial-genetic perspective, the catatonia phenotype in psychotic and mood disorders has a transdiagnostic character. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据