期刊
SCHIZOPHRENIA RESEARCH
卷 184, 期 -, 页码 69-72出版社
ELSEVIER
DOI: 10.1016/j.schres.2016.12.003
关键词
Childhood trauma; fMRI functional connectivity; Schizophrenia; Amygdala; Precuneus; Posterior cingulate cortex
类别
资金
- Bristol-Myers Squibb Company & Otsuka Pharmaceutical Company
- Multi-agency Thematic Institute (ITMO) [DR12 CP083469]
- Pierre Houriez Foundation
Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia. (C) 2016 Elsevier B.V. All rights reserved.
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