期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 31, 期 2, 页码 150-165出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajh/hpx197
关键词
atherosclerosis; biomarker; blood pressure; hypertension; microRNA; miRNA; myocardial infarction; ncRNA; noncoding RNA
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [DK099475]
Noncoding RNAs (ncRNA) include a diverse range of functional RNA species-microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) being most studied in pathophysiology. Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease. A single miRNA may have hundreds of messenger RNA targets, which makes a full appreciation of the physiologic ramifications of such broad-ranging effects a challenge. miR-21 is the most prominent ncRNA associated with hypertension and atherosclerotic disease due to its role as a mechano-miR, responding to arterial shear stresses. Immuno-miRs, such as miR-155 and miR-223, affect cardiovascular disease (CVD) via regulation of hematopoietic cell differentiation, chemotaxis, and activation in response to many pro-atherogenic stimuli. Myo-miRs, such as miR-1 and miR-133, affect cardiac muscle plasticity and remodeling in response to mechanical overload. This in-depth review analyzes observational and experimental reports of ncRNAs in CVD, including future applications of ncRNA-based strategies in diagnosis, prediction (e.g., survival and response to small molecule therapy), and biologic therapy.
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