期刊
SCHIZOPHRENIA BULLETIN
卷 44, 期 2, 页码 378-387出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbx078
关键词
auditory; hallucination; working memory; schizophrenia; auditory steady state; delta; gamma; ASSR
类别
资金
- National Institutes of Health [R01MH085646, U01MH108148, P50MH103222, R01DA027680, R01DC014085]
- University of Maryland [14-103]
Background: Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients. Methods: Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradigm, along with those from theta (5 Hz), alpha (10 Hz), beta (20 Hz), gamma (40 Hz), and high gamma (80 Hz) frequency ASSR, were compared in 128 patients with schizophrenia, 108 healthy controls, and 55 first-degree relatives (FDR) of patients. Results: Delta band synchronization was significantly impaired in patients compared with controls (F = 18.3, P <.001). There was a significant 2.5 Hz by 40 Hz ASSR interaction (P = .023), arising from a greater reduction of 2.5 Hz ASSR than of 40 Hz ASSR, in patients compared with controls. Greater deficit in delta ASSR was associated with auditory perceptual abnormality (P = .007) and reduced verbal working memory (P <.001). Gamma frequency ASSR impairment was also significant but more modest (F = 8.7, P = .004), and this deficit was also present in FDR (P = .022). Conclusions: The ability to sustain delta band oscillation entrainment in the auditory pathway is significantly reduced in schizophrenia patients and appears to be clinically relevant.
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