期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 49, 期 16, 页码 10147-10154出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.5b02220
关键词
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资金
- Ministry of Education of China [IRT 13024]
- National Natural Science Foundation of China [31170473, U1133006, 21307061, 21407085]
- Tianjin Natural Science Foundation [14JCQNJC08900]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [2013003112016]
- Postdoctoral Science Foundation of China [2014M550138]
Graphene oxide (GO) is a widely used carbonaceous nanomaterial. To date, the influence of natural organic matter (NOM) on GO toxicity in aquatic vertebrates has not been reported. During zebrafish embryogenesis, GO induced a significant hatching delay and cardiac edema. The intensive interactions of GO with the chorion induces damage to chorion protuberances, excessive generation of (OH)-O-center dot, and changes in protein secondary structure. In contrast, humic acid (HA), a ubiquitous form of NOM, significantly relieved the above adverse effects. HA reduced the interactions between GO and the chorion and mitigated chorion damage by regulating the morphology, structures, and surface negative charges of GO. HA also altered the uptake and deposition of GO and decreased the aggregation of GO in embryonic yolk cells and deep layer cells. Furthermore, HA mitigated the mitochondrial damage and oxidative stress induced by GO. This work reveals a feasible antidotal mechanism for GO in the presence of NOM and avoids overestimating the risks of GO in the natural environment.
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