期刊
ACTA ODONTOLOGICA SCANDINAVICA
卷 76, 期 2, 页码 130-134出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016357.2017.1392601
关键词
Radiation; implant; dental; experimental study
Background: Radiotherapy is a commonly used treatment modality in head and neck cancer; however, it also negatively affects healthy structures. Direct damage to oral soft and hard tissue frequently occurs with radiotherapy. In this study, we aimed to evaluate the effect of radiotherapy on bone surrounding titanium dental implants via biomechanical and molecular methods. Materials and methods: Fifty-four implants were inserted in the left tibiae of 18 adult male New Zealand rabbits (3 implants in each rabbit). After 4 weeks of the implant surgery, the left tibiae of 12 rabbits were subjected to a single dose of irradiation (15Gy or 30Gy). Four weeks after the irradiation, rabbits were sacrificed and removal torque test was done for the biomechanical evaluation. Bone morphogenetic protein-2 (Bmp-2) and fibroblast growth factor-2 (Fgf-2) expression analyses were performed with Real-time PCR. Statistical analysis was done using SPSS. Results: The control group showed significantly higher removal torque value than the 15 and 30 Gy irradiation groups, and the 15Gy irradiation group had higher removal torque value than the 30 Gy irradiation group (p<.001). The 15 Gy and 30 Gy irradiation groups had significantly lower Bmp-2 and Fgf-2 mRNA expressions than the control group (p<.001). In addition, the 30Gy irradiation group had significantly lower Bmp-2 (p<.01) and Fgf-2 mRNA expressions (p<.001) than the 15 Gy group. Conclusion: Radiotherapy with 15 and 30Gy doses can adversely affect osseointegration of implants by reducing the quality of bone and impairing the bone-to-implant contact. The mechanism of action seems to be related to alterations in Bmp-2 and Fgf-2 mRNA expressions.
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