期刊
ECANCERMEDICALSCIENCE
卷 12, 期 -, 页码 -出版社
CANCER INTELLIGENCE LTD
DOI: 10.3332/ecancer.2018.803
关键词
endometriosis; ovarian cancer; molecular mechanisms; biomarkers
类别
资金
- Cararresi Foundation (OvCaRe Research Grant)
- Canadian Institutes of Health Research (CIHR)
- British Columbia Cancer Foundation (BCCF)
- VGH-UBC Hospital Foundation
Endometriosis is a fascinating disease that we strive to better understand. Molecular techniques are shedding new light on many important aspects of this disease: from pathogenesis to the recognition of distinct disease variants like deep infiltrating endometriosis. The observation that endometriosis is a cancer precursor has now been strengthened with the knowledge that mutations that are present in endometriosis-associated cancers can be found in adjacent endometriosis lesions. Recent genomic studies, placed in context, suggest that deep infiltrating endometriosis may represent a benign neoplasm that invades locally but rarely metastasises. Further research will help elucidate distinct aberrations which result in this phenotype. With respect to identifying those patients who may be at risk of developing endometriosis-associated cancers, a combination of molecular, pathological, and inheritance markers may define a high-risk group that might benefit from risk-reducing strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据